This data is for laboratory research purposes only. Not for human or animal consumption.
What is MGF?
Mechano Growth Factor (MGF) is a splice variant of IGF-1 produced by skeletal muscle in response to mechanical loading or injury. It acts locally as an autocrine/paracrine signal to activate satellite cells for muscle fiber repair and hypertrophy.
Mechanism of Action
Mechanical stretch triggers alternative splicing of the IGF-1 gene to produce MGF, which activates muscle satellite cells (the muscle stem cell population) for fusion with damaged fibers and hypertrophic adaptation. MGF has a short half-life of minutes, distinguishing it from PEG-MGF.
Observed Laboratory Results
- Satellite cell activation at sites of mechanical loading or damage
- Short half-life of minutes versus hours for PEG-MGF
- Local autocrine/paracrine action versus systemic IGF-1
- Induction by eccentric exercise in human muscle biopsy studies
Comparison to PEG-MGF
The PEG-MGF variant adds polyethylene glycol to extend half-life and enable sustained-release research, while native MGF preserves the natural pulsatile, locally restricted signal.