Neurological

Pinealon

Research Reagent · Laboratory Use Only

Quick Answer

What is Pinealon and how is it different from Epitalon?

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) from the Khavinson short peptide bioregulator family, investigated for neuroprotection and circadian rhythm regulation. Unlike Epitalon (a tetrapeptide focused on telomerase activation), Pinealon targets neuronal gene expression in pineal and hypothalamic tissue.

PMID21161680↗DOI10.1007/s10517-010-1066-1↗⟳ Reconstitution Calculator

Scientific AbstractPMID 21161680 · 2010

Pinealon is a synthetic short peptide (Glu-Asp-Arg) developed in the Russian peptide bioregulator research tradition (Khavinson and colleagues, St. Petersburg Institute of Bioregulation and Gerontology). Research suggests effects on neuronal gene expression, regulation of circadian rhythm-associated pathways, and neuroprotection in age-related cognitive decline models.

Mechanistic studies focus on epigenetic modulation and direct interaction with DNA in pineal and hypothalamic neurons. Pinealon is investigated alongside other Khavinson bioregulators including Epitalon and Cortexin.

Source:10.1007/s10517-010-1066-1

Mechanistic Research SummaryCurated from PubMed

This data is for laboratory research purposes only. Not for human or animal consumption.

What is Pinealon?

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) belonging to the Khavinson short peptide bioregulator family investigated for effects on circadian regulation, neuroprotection, and age-related cognitive decline.

Mechanism of Action

Khavinson-family peptides are hypothesized to act via direct DNA interaction in cell nuclei, modulating gene expression in tissue-specific patterns. Pinealon is studied for activity in pineal gland and hypothalamic neurons with downstream effects on circadian rhythm pathways.

Observed Laboratory Results

Neuroprotection in age-related cognitive decline models
Circadian rhythm pathway modulation in pineal and hypothalamic tissue
Gene expression effects in neuronal cell populations
Bioregulator family member alongside Epitalon and Cortexin

Clinical Research Parameters

1 human study

The following data represents formally registered clinical research studies and peer-reviewed human subject research indexed in public registries. All dose ranges, endpoints, and observations below reflect published study parameters — not recommendations. For research reference only.

Indexed Human Subject Research

Search PubMed ↗

24969690

Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats.

Khavinson VK et al.Mech Ageing Dev1994 Nov

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Research Compliance Notice

All data presented on this page is for laboratory research purposes only. Pinealon is referenced here as a research reagent. This page does not constitute medical advice, clinical guidance, or endorsement of any compound for human or animal use. All referenced studies are available via PubMed (PMID: 21161680) and the DOI-linked journal publication. Researchers must consult applicable institutional and regulatory frameworks before conducting any protocols.

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